Water → HCID 59406463, compound

HRID 2060087Notes

Reaction equation

HRID 2060087 reaction equation
[N:1]([CH2:4][C:5]1[N:9]([C:10]2[CH:15]=[CH:14][C:13]([S:16]([CH3:19])(=[O:18])=[O:17])=[CH:12][CH:11]=2)[N:8]=[CH:7][CH:6]=1)=[N+]=[N-].O.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>O1CCOCC1>[CH3:19][S:16]([C:13]1[CH:12]=[CH:11][C:10]([N:9]2[C:5]([CH2:4][NH2:1])=[CH:6][CH:7]=[N:8]2)=[CH:15][CH:14]=1)(=[O:17])=[O:18]

Participants

5

Reactant 3

HCID 962WaterHCID 11776TriphenylphosphineHCID 59406417HCID 59406417, compound

Product 1

HCID 59406463HCID 59406463, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of 5-azidomethyl-1-(4-methanesulfonyl-phenyl)-1H-pyrazole (0.344 g, 1.24 mmol, 1.00 equiv) in 1,4-dioxane (5 mL) was added water (0.5 mL) and triphenylphosphine resin (0.5 g, 3 mol/g, 200-400 mesh, 1.2 equiv). The suspension was stirred overnight. Filtration and concentration afforded C-[2-(4-methanesulfonyl-phenyl)-2H-pyrazol-3-yl]-methylamine as a colorless solid.

Workup

  1. filtrationFiltration and concentration

Sources & evidence

ORD record
ord-c4d6706d52744fd0ba088bd1099b13a7
Source dataset
uspto-grants-2012_10
Patent number
US08278337B2

Reaction notes

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