4-Fluorobenzoyl chloride → 1-(4-Fluoro-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester

HRID 2060232Notes

Reaction equation

HRID 2060232 reaction equation
[CH2:1]([O:3][C:4]([CH:6]1[CH2:10][CH2:9][NH:8][CH2:7]1)=[O:5])[CH3:2].[F:11][C:12]1[CH:20]=[CH:19][C:15]([C:16](Cl)=[O:17])=[CH:14][CH:13]=1>>[CH2:1]([O:3][C:4]([CH:6]1[CH2:10][CH2:9][N:8]([C:16](=[O:17])[C:15]2[CH:19]=[CH:20][C:12]([F:11])=[CH:13][CH:14]=2)[CH2:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 12896002Ethyl pyrrolidine-3-carboxylate

Product 1

HCID 593222251-(4-Fluoro-benzoyl)-pyrrolidine-3-carboxylic acid ethyl esterYield 76%

Procedure

The title compound was prepared according to the method described for Preparation 2 using pyrrolidine-3-carboxylic acid ethyl ester (see Preparation 1) and 4-fluoro-benzoyl chloride to afford the title compound as a colourless oil (4.3 g, 76%).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-9b6598db7363478d85e9bd0569732f71
Source dataset
uspto-grants-2012_10
Patent number
US08278343B2

Reaction notes

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