2-Chloro-5-fluoropyrimidine → HCID 136146137, compound

HRID 2060245Notes

Reaction equation

HRID 2060245 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5](B(O)O)=[CH:4][CH:3]=1.Cl[C:12]1[N:17]=[CH:16][C:15]([F:18])=[CH:14][N:13]=1>>[F:18][C:15]1[CH:14]=[N:13][C:12]([C:5]2[CH:6]=[CH:7][C:2]([OH:1])=[CH:3][CH:4]=2)=[N:17][CH:16]=1

Participants

3

Reactant 2

HCID 5834662-Chloro-5-fluoropyrimidineHCID 27343604-Hydroxyphenylboronic acid

Product 1

HCID 136146137HCID 136146137, compoundYield 42%

Procedure

The title compound was prepared according to the method described for Preparation 17 using 4-hydroxybenzene boronic acid and 2-chloro-5-fluoro-pyrimidine to afford the title compound as a white solid (575 mg, 42%)

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-060ab243f8ae46808dc9440a76d26a95
Source dataset
uspto-grants-2012_10
Patent number
US08278343B2

Reaction notes

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