3-Methoxyphenyl isocyanate → 3-(4'-Fluoro-biphenyl-4-yloxymethyl)-1-(3-methoxy-phenylcarbamoyl)pyrrolidine-3-carboxylic acid ethyl ester
Reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:9]=[C:10]=[O:11])[CH:6]=[CH:7][CH:8]=1.[CH2:12]([O:14][C:15]([C:17]1([CH2:22][O:23][C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=3)=[CH:26][CH:25]=2)[CH2:21][CH2:20][NH:19][CH2:18]1)=[O:16])[CH3:13]>>[CH2:12]([O:14][C:15]([C:17]1([CH2:22][O:23][C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:31]=[CH:32][C:33]([F:36])=[CH:34][CH:35]=3)=[CH:26][CH:25]=2)[CH2:21][CH2:20][N:19]([C:10](=[O:11])[NH:9][C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=2)[CH2:18]1)=[O:16])[CH3:13]Participants
3
Procedure
The title compound was prepared according to the method described for Preparation using 3-methoxy phenyl isocyanate and 3-(4′-fluoro-biphenyl-4-yloxymethyl)-pyrrolidine-3-carboxylic acid ethyl ester (Preparation 65) to afford a racemate as a colourless liquid (230 mg, 80%)
Workup
- customdescribed for Preparation
Sources & evidence
- ORD record
- ord-a4bc8d738ce04d41a2aeeeb443b2a499
- Source dataset
- uspto-grants-2012_10
- Patent number
- US08278343B2
Reaction notes
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