HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methoxyphenyl isocyanate → 3-(4'-Fluoro-biphenyl-4-yloxymethyl)-1-(3-methoxy-phenylcarbamoyl)pyrrolidine-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methoxyphenyl isocyanate | HCID 87843 | — |
| Reactant | 3-(4'-Fluoro-biphenyl-4-yloxymethyl)-pyrrolidine-3-carboxylic acid ethyl ester | HCID 59322195 | — |
| Product | 3-(4'-Fluoro-biphenyl-4-yloxymethyl)-1-(3-methoxy-phenylcarbamoyl)pyrrolidine-3-carboxylic acid ethyl ester | HCID 59322189 | — |
Reaction Steps
The title compound was prepared according to the method described for Preparation using 3-methoxy phenyl isocyanate and 3-(4′-fluoro-biphenyl-4-yloxymethyl)-pyrrolidine-3-carboxylic acid ethyl ester (Preparation 65) to afford a racemate as a colourless liquid (230 mg, 80%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278343B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-a4bc8d738ce04d41a2aeeeb443b2a499 |
| Source note | uspto-grants-2012_10 |