2-Fluorophenyl isocyanate → 3-(4'-Fluoro-biphenyl-4-yloxymethyl)-1-(2-fluoro-phenylcarbamoyl)-pyrrolidine-3-carboxylic acid ethyl ester
Reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]=[C:9]=[O:10].[CH2:11]([O:13][C:14]([C:16]1([CH2:21][O:22][C:23]2[CH:28]=[CH:27][C:26]([C:29]3[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=3)=[CH:25][CH:24]=2)[CH2:20][CH2:19][NH:18][CH2:17]1)=[O:15])[CH3:12]>>[CH2:11]([O:13][C:14]([C:16]1([CH2:21][O:22][C:23]2[CH:28]=[CH:27][C:26]([C:29]3[CH:30]=[CH:31][C:32]([F:35])=[CH:33][CH:34]=3)=[CH:25][CH:24]=2)[CH2:20][CH2:19][N:18]([C:9](=[O:10])[NH:8][C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[F:1])[CH2:17]1)=[O:15])[CH3:12]Participants
3
Procedure
The title compound was prepared according to the method described for Preparation 71 using 2-fluoro phenyl isocyanate and 3-(4′-fluoro-biphenyl-4-yloxymethyl)-pyrrolidine-3-carboxylic acid ethyl ester (Preparation 65) to afford the racemate as a colourless liquid (230 mg, 82%)
Sources & evidence
- ORD record
- ord-4e38e99a77e24879941572373fe7d6e3
- Source dataset
- uspto-grants-2012_10
- Patent number
- US08278343B2
Reaction notes
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