HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluorophenyl isocyanate → 3-(4'-Fluoro-biphenyl-4-yloxymethyl)-1-(2-fluoro-phenylcarbamoyl)-pyrrolidine-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluorophenyl isocyanate | HCID 85588 | — |
| Reactant | 3-(4'-Fluoro-biphenyl-4-yloxymethyl)-pyrrolidine-3-carboxylic acid ethyl ester | HCID 59322195 | — |
| Product | 3-(4'-Fluoro-biphenyl-4-yloxymethyl)-1-(2-fluoro-phenylcarbamoyl)-pyrrolidine-3-carboxylic acid ethyl ester | HCID 59322233 | — |
Reaction Steps
The title compound was prepared according to the method described for Preparation 71 using 2-fluoro phenyl isocyanate and 3-(4′-fluoro-biphenyl-4-yloxymethyl)-pyrrolidine-3-carboxylic acid ethyl ester (Preparation 65) to afford the racemate as a colourless liquid (230 mg, 82%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278343B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-4e38e99a77e24879941572373fe7d6e3 |
| Source note | uspto-grants-2012_10 |