Cyclopentanecarbonyl chloride → 1-Cyclopentanecarbonyl-3-(4'-fluoro-biphenyl-4-yloxymethyl)pyrrolidine-3-carboxylic acid ethyl ester
Reaction equation
[CH:1]1([C:6](Cl)=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:9]([O:11][C:12]([C:14]1([CH2:19][O:20][C:21]2[CH:26]=[CH:25][C:24]([C:27]3[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=3)=[CH:23][CH:22]=2)[CH2:18][CH2:17][NH:16][CH2:15]1)=[O:13])[CH3:10]>>[CH2:9]([O:11][C:12]([C:14]1([CH2:19][O:20][C:21]2[CH:26]=[CH:25][C:24]([C:27]3[CH:28]=[CH:29][C:30]([F:33])=[CH:31][CH:32]=3)=[CH:23][CH:22]=2)[CH2:18][CH2:17][N:16]([C:6]([CH:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)=[O:7])[CH2:15]1)=[O:13])[CH3:10]Participants
3
Procedure
The title compound was prepared according to the method described for Preparation 76 using cyclopentanecarbonyl chloride and 3-(4′-fluoro-biphenyl-4-yloxymethyl)-pyrrolidine-3-carboxylic acid ethyl ester (Preparation 65) to afford the racemate as a white solid (120 mg, 94%)
Sources & evidence
- ORD record
- ord-31290790728c4ccc83500eb4951ab55c
- Source dataset
- uspto-grants-2012_10
- Patent number
- US08278343B2
Reaction notes
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