HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopentanecarbonyl chloride → 1-Cyclopentanecarbonyl-3-(4'-fluoro-biphenyl-4-yloxymethyl)pyrrolidine-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopentanecarbonyl chloride | HCID 78284 | — |
| Reactant | 3-(4'-Fluoro-biphenyl-4-yloxymethyl)-pyrrolidine-3-carboxylic acid ethyl ester | HCID 59322195 | — |
| Product | 1-Cyclopentanecarbonyl-3-(4'-fluoro-biphenyl-4-yloxymethyl)pyrrolidine-3-carboxylic acid ethyl ester | HCID 59322217 | — |
Reaction Steps
The title compound was prepared according to the method described for Preparation 76 using cyclopentanecarbonyl chloride and 3-(4′-fluoro-biphenyl-4-yloxymethyl)-pyrrolidine-3-carboxylic acid ethyl ester (Preparation 65) to afford the racemate as a white solid (120 mg, 94%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278343B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-31290790728c4ccc83500eb4951ab55c |
| Source note | uspto-grants-2012_10 |