Pentanal → HCID 57923948, compound

HRID 2060303Notes

Reaction equation

HRID 2060303 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][NH2:9])[CH:5]=[CH:4][N:3]=[CH:2]1.[CH:10](=O)[CH2:11][CH2:12][CH2:13][CH3:14].C(O[C:19](=[O:29])[C:20](=[O:28])[CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)C>C(O)C>[CH2:11]([CH:10]1[N:9]([CH2:8][CH2:7][CH2:6][N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)[C:19](=[O:29])[C:20]([OH:28])=[C:21]1[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)[CH2:12][CH2:13][CH3:14]

Participants

5

Reactant 3

HCID 8063PentanalHCID 787361H-Imidazole-1-propanamineHCID 12292599Ethyl 2-oxo-3-phenylpropanoate

Product 1

HCID 57923948HCID 57923948, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

3-Imidazol-1-yl-propylamine (1 mmol) and pentanal (1 mmol) were added to ethanol (5 ml). After 30 min 2-Oxo-3-phenyl-propionic acid ethylester (1 mmol) was added. The reaction was heated to 50° C. and stirred for 24 h. After evaporation of the solvent the residue was purified with chromatographic methods.

Workup

  1. customAfter evaporation of the solvent the residue
  2. customwas purified with chromatographic methods

Sources & evidence

ORD record
ord-7ee580f2e2c74e03bc97980480a1fb53
Source dataset
uspto-grants-2012_10
Patent number
US08278345B2

Reaction notes

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