Acrolein dimer → HCID 57924147, compound

HRID 2060309Notes

Reaction equation

HRID 2060309 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][NH2:9])[CH:5]=[CH:4][N:3]=[CH:2]1.[O:10]1[CH:15]=[CH:14][CH2:13][CH2:12][CH:11]1[CH:16]=O.C([O:20][C:21](=O)[C:22](=[O:33])[CH2:23][C:24]1[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[NH:26][CH:25]=1)C>C(O)C>[O:10]1[CH:15]=[CH:14][CH2:13][CH2:12][CH:11]1[CH:16]1[N:9]([CH2:8][CH2:7][CH2:6][N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)[C:21](=[O:20])[C:22]([OH:33])=[C:23]1[C:24]1[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[NH:26][CH:25]=1

Participants

5

Reactant 3

HCID 60994Acrolein dimerHCID 787361H-Imidazole-1-propanamineHCID 12457675HCID 12457675, compound

Product 1

HCID 57924147HCID 57924147, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

3-Imidazol-1-yl-propylamine (1 mmol) and 3,4-Dihydro-2H-pyran-2-carbaldehyde (1 mmol) were added to ethanol (5 ml). After 30 min 3-(1H-Indol-3-yl)-2-oxo-propionic acid ethyl ester (1 mmol) was added. The reaction was heated to 50° C. and stirred for 24 h. After evaporation of the solvent the residue was purified with chromatographic methods.

Workup

  1. customAfter evaporation of the solvent the residue
  2. customwas purified with chromatographic methods

Sources & evidence

ORD record
ord-6631e29c1e6049f8a4102a9b34e7e739
Source dataset
uspto-grants-2012_10
Patent number
US08278345B2

Reaction notes

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