5-Methylfurfural → 3-Hydroxy-1-(3-imidazol-1-yl-propyl)-5-(5-methyl-furan-2-yl)-4-pentyl-1,5-dihydro-pyrrol-2-one

HRID 2060317Notes

Reaction equation

HRID 2060317 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][NH2:9])[CH:5]=[CH:4][N:3]=[CH:2]1.[CH3:10][C:11]1[O:15][C:14]([CH:16]=O)=[CH:13][CH:12]=1.C([O:20][C:21](=O)[C:22](=[O:29])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])C>C(O)C>[OH:29][C:22]1[C:21](=[O:20])[N:9]([CH2:8][CH2:7][CH2:6][N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)[CH:16]([C:14]2[O:15][C:11]([CH3:10])=[CH:12][CH:13]=2)[C:23]=1[CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]

Participants

5

Reactant 3

HCID 120975-MethylfurfuralHCID 787361H-Imidazole-1-propanamineHCID 10888659Ethyl 2-oxooctanoate

Product 1

HCID 579239133-Hydroxy-1-(3-imidazol-1-yl-propyl)-5-(5-methyl-furan-2-yl)-4-pentyl-1,5-dihydro-pyrrol-2-one

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3-Imidazol-1-yl-propylamine (1 mmol) and 5-Methyl-furan-2-carbaldehyde (1 mmol) were added to ethanol (5 ml). After 30 min 2-Oxo-octanoic acid ethyl ester (1 mmol) was added.

Sources & evidence

ORD record
ord-dff73c9e24e645e294aa4de5fefc730f
Source dataset
uspto-grants-2012_10
Patent number
US08278345B2

Reaction notes

Loading…