5-Methylfurfural → HCID 178450348, compound

HRID 2060325Notes

Reaction equation

HRID 2060325 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[N:3]=[CH:2]1.[CH3:11][C:12]1[O:16][C:15]([CH:17]=O)=[CH:14][CH:13]=1.C([O:21][C:22](=O)[C:23](=[O:30])[CH2:24][C:25](=[O:29])[CH2:26][CH2:27][CH3:28])C>C(O)C>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]3[CH:17]([C:15]4[O:16][C:12]([CH3:11])=[CH:13][CH:14]=4)[C:24]([C:25](=[O:29])[CH2:26][CH2:27][CH3:28])=[C:23]([OH:30])[C:22]3=[O:21])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

5

Reactant 3

HCID 120975-MethylfurfuralHCID 3006750Ethyl 2,4-dioxoheptanoateHCID 178507353HCID 178507353, compound

Product 1

HCID 178450348HCID 178450348, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

1H-Benzoimidazol-5-ylamine (1 mmol) and 5-Methyl-furan-2-carbaldehyde (1 mmol) were added to ethanol (5 ml). After 30 min 2,4-Dioxo-heptanoic acid ethyl ester (1 mmol) was added. The reaction was heated to 50° C. and stirred for 24 h. After evaporation of the solvent the residue was purified with chromatographic methods.

Workup

  1. customAfter evaporation of the solvent the residue
  2. customwas purified with chromatographic methods

Sources & evidence

ORD record
ord-16781ed0ff2b452ca85cfa873effc2d6
Source dataset
uspto-grants-2012_10
Patent number
US08278345B2

Reaction notes

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