2,1,3-Benzothiadiazole-5-carbaldehyde → HCID 178519910, compound

HRID 2060328Notes

Reaction equation

HRID 2060328 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[N:3]=[CH:2]1.[N:11]1[S:15][N:14]=[C:13]2[CH:16]=[C:17]([CH:20]=O)[CH:18]=[CH:19][C:12]=12.C([O:24][C:25](=O)[C:26](=[O:33])[CH2:27][C:28]([CH:30]1[CH2:32][CH2:31]1)=[O:29])C>C(O)C>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]3[CH:20]([C:17]4[CH:18]=[CH:19][C:12]5=[N:11][S:15][N:14]=[C:13]5[CH:16]=4)[C:27]([C:28]([CH:30]4[CH2:32][CH2:31]4)=[O:29])=[C:26]([OH:33])[C:25]3=[O:24])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

5

Reactant 3

HCID 27762902,1,3-Benzothiadiazole-5-carbaldehydeHCID 16779961Ethyl 4-cyclopropyl-2,4-dioxobutanoateHCID 178507353HCID 178507353, compound

Product 1

HCID 178519910HCID 178519910, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

1H-Benzoimidazol-5-ylamine (1 mmol) and Benzo[1,2,5]thiadiazole-5-carbaldehyde (1 mmol) were added to ethanol (5 ml). After 30 min 4-Cyclopropyl-2,4-dioxo-butyric acid ethyl ester (1 mmol) was added. The reaction was heated to 50° C. and stirred for 24 h. After evaporation of the solvent the residue was purified with chromatographic methods.

Workup

  1. customAfter evaporation of the solvent the residue
  2. customwas purified with chromatographic methods

Sources & evidence

ORD record
ord-16dcceae8bda4b3897834feb287dc9f5
Source dataset
uspto-grants-2012_10
Patent number
US08278345B2

Reaction notes

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