8-Hydroxy-2-quinolinecarboxaldehyde → HCID 178446986, compound

HRID 2060329Notes

Reaction equation

HRID 2060329 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[N:3]=[CH:2]1.[OH:11][C:12]1[CH:13]=[CH:14][CH:15]=[C:16]2[C:21]=1[N:20]=[C:19]([CH:22]=O)[CH:18]=[CH:17]2.C([O:26][C:27](=O)[C:28](=[O:36])[CH2:29][C:30](=[O:35])[CH2:31][CH:32]([CH3:34])[CH3:33])C>C(O)C>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]3[CH:22]([C:19]4[CH:18]=[CH:17][C:16]5[C:21](=[C:12]([OH:11])[CH:13]=[CH:14][CH:15]=5)[N:20]=4)[C:29]([C:30](=[O:35])[CH2:31][CH:32]([CH3:34])[CH3:33])=[C:28]([OH:36])[C:27]3=[O:26])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

5

Reactant 3

HCID 5993428-Hydroxy-2-quinolinecarboxaldehydeHCID 3006751ethyl 6-methyl-2,4-dioxoheptanoateHCID 178507353HCID 178507353, compound

Product 1

HCID 178446986HCID 178446986, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

1H-Benzoimidazol-5-ylamine (1 mmol) and 8-Hydroxy-quinoline-2-carbaldehyde (1 mmol) were added to ethanol (5 ml). After 30 min 6-Methyl-2,4-dioxo-heptanoic acid ethyl ester (1 mmol) was added. The reaction was heated to 50° C. and stirred for 24 h. After evaporation of the solvent the residue was purified with chromatographic methods.

Workup

  1. customAfter evaporation of the solvent the residue
  2. customwas purified with chromatographic methods

Sources & evidence

ORD record
ord-39ce91dfa05f448e8b62668caaa33045
Source dataset
uspto-grants-2012_10
Patent number
US08278345B2

Reaction notes

Loading…