5-Chloro-salicylaldehyde → HCID 178503662, compound

HRID 2060330Notes

Reaction equation

HRID 2060330 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[N:3]=[CH:2]1.[Cl:11][C:12]1[CH:13]=[CH:14][C:15]([OH:20])=[C:16]([CH:19]=1)[CH:17]=O.C([O:23][C:24](=O)[C:25](=[O:30])[CH2:26][CH2:27][S:28][CH3:29])C>C(O)C>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]3[CH:17]([C:16]4[CH:19]=[C:12]([Cl:11])[CH:13]=[CH:14][C:15]=4[OH:20])[C:26]([CH2:27][S:28][CH3:29])=[C:25]([OH:30])[C:24]3=[O:23])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

5

Reactant 3

HCID 124815-Chloro-salicylaldehydeHCID 102413204-Methylsulfanyl-2-oxo-butyric acid ethyl esterHCID 178507353HCID 178507353, compound

Product 1

HCID 178503662HCID 178503662, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

1H-Benzoimidazol-5-ylamine (1 mmol) and 5-Chloro2-Hydroxybenzaldehyde (1 mmol) were added to ethanol (5 ml). After 30 min 4-Methylsulfanyl-2-oxo-butyric acid ethyl ester (1 mmol) was added. The reaction was heated to 50° C. and stirred for 24 h. After evaporation of the solvent the residue was purified with chromatographic methods.

Workup

  1. customAfter evaporation of the solvent the residue
  2. customwas purified with chromatographic methods

Sources & evidence

ORD record
ord-bbf27d6075834a9ab4bd2eb20032579e
Source dataset
uspto-grants-2012_10
Patent number
US08278345B2

Reaction notes

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