3-Quinolinecarboxaldehyde → HCID 178516874, compound

HRID 2060336Notes

Reaction equation

HRID 2060336 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[N:3]=[CH:2]1.[N:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[C:13]([CH:21]=O)[CH:12]=1.C([O:25][C:26](=O)[C:27](=[O:35])[CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)C>C(O)C>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]3[CH:21]([C:13]4[CH:12]=[N:11][C:20]5[C:15]([CH:14]=4)=[CH:16][CH:17]=[CH:18][CH:19]=5)[C:28]([C:29]4[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=4)=[C:27]([OH:35])[C:26]3=[O:25])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

5

Reactant 3

HCID 836413-QuinolinecarboxaldehydeHCID 12292599Ethyl 2-oxo-3-phenylpropanoateHCID 178507353HCID 178507353, compound

Product 1

HCID 178516874HCID 178516874, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

1H-Benzoimidazol-5-ylamine (1 mmol) and Quinoline-3-carbaldehyde (1 mmol) were added to ethanol (5 ml). After 30 min 2-Oxo-3-phenyl-propionic acid ethyl ester (1 mmol) was added. The reaction was heated to 50° C. and stirred for 24 h. After evaporation of the solvent the residue was purified with chromatographic methods.

Workup

  1. customAfter evaporation of the solvent the residue
  2. customwas purified with chromatographic methods

Sources & evidence

ORD record
ord-d9fe1272f1d84cabb58e643f089d648d
Source dataset
uspto-grants-2012_10
Patent number
US08278345B2

Reaction notes

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