Benzo(c)(1,2,5)oxadiazole-5-carbaldehyde → HCID 178450346, compound

HRID 2060337Notes

Reaction equation

[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[N:3]=[CH:2]1.[N:11]1[O:15][N:14]=[C:13]2[CH:16]=[C:17]([CH:20]=O)[CH:18]=[CH:19][C:12]=12.C([O:24][C:25](=O)[C:26](=[O:33])[CH2:27][C:28](=[O:32])[CH2:29][CH2:30][CH3:31])C>C(O)C>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]3[CH:20]([C:17]4[CH:18]=[CH:19][C:12]5=[N:11][O:15][N:14]=[C:13]5[CH:16]=4)[C:27]([C:28](=[O:32])[CH2:29][CH2:30][CH3:31])=[C:26]([OH:33])[C:25]3=[O:24])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

Conditions

Temperature: 50 °C

Procedure

1H-Benzoimidazol-5-ylamine (1 mmol) and Benzo[1,2,5]oxadiazole-5-carbaldehyde (1 mmol) were added to ethanol (5 ml). After 30 min 2,4-Dioxo-heptanoic acid ethyl ester (1 mmol) was added. The reaction was heated to 50° C. and stirred for 24 h. After evaporation of the solvent the residue was purified with chromatographic methods.

Workup

customAfter evaporation of the solvent the residue
customwas purified with chromatographic methods

Sources & evidence

ORD record: ord-75f734811ca04cd6b2e7771c160718d9
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08278345B2

Reaction notes

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