3-Quinolinecarboxaldehyde → HCID 178516883, compound

HRID 2060338Notes

Reaction equation

[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[N:3]=[CH:2]1.[N:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[C:13]([CH:21]=O)[CH:12]=1.C([O:25][C:26](=O)[C:27](=[O:38])[CH2:28][C:29]1[C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[NH:31][CH:30]=1)C>C(O)C>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]3[CH:21]([C:13]4[CH:12]=[N:11][C:20]5[C:15]([CH:14]=4)=[CH:16][CH:17]=[CH:18][CH:19]=5)[C:28]([C:29]4[C:37]5[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=5)[NH:31][CH:30]=4)=[C:27]([OH:38])[C:26]3=[O:25])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

Conditions

Temperature: 50 °C

Procedure

1H-Benzoimidazol-5-ylamine (1 mmol) and Quinoline-3-carbaldehyde (1 mmol) were added to ethanol (5 ml). After 30 min 3-(1H-Indol-3-yl)-2-oxo-propionic acid ethyl ester (1 mmol) was added. The reaction was heated to 50° C. and stirred for 24 h. After evaporation of the solvent the residue was purified with chromatographic methods.

Workup

customAfter evaporation of the solvent the residue
customwas purified with chromatographic methods

Sources & evidence

ORD record: ord-c11fc773ed9a42b4a0eac3c47e1ce7fe
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08278345B2

Reaction notes

Loading…