2,3,5-Trifluorobenzaldehyde → HCID 178516873, compound

HRID 2060341Notes

Reaction equation

HRID 2060341 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[N:3]=[CH:2]1.[F:11][C:12]1[C:19]([F:20])=[CH:18][C:17]([F:21])=[CH:16][C:13]=1[CH:14]=O.C([O:24][C:25](=O)[C:26](=[O:34])[CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)C>C(O)C>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]3[CH:14]([C:13]4[CH:16]=[C:17]([F:21])[CH:18]=[C:19]([F:20])[C:12]=4[F:11])[C:27]([C:28]4[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=4)=[C:26]([OH:34])[C:25]3=[O:24])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

5

Reactant 3

HCID 27769502,3,5-TrifluorobenzaldehydeHCID 12292599Ethyl 2-oxo-3-phenylpropanoateHCID 178507353HCID 178507353, compound

Product 1

HCID 178516873HCID 178516873, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

1H-Benzoimidazol-5-ylamine (1 mmol) and 2,3,5 Trifluorobenzaldehyde (1 mmol) were added to ethanol (5 ml). After 30 min 2-Oxo-3-phenyl-propionic acid ethyl ester (1 mmol) was added. The reaction was heated to 50° C. and stirred for 24 h. After evaporation of the solvent the residue was purified with chromatographic methods.

Workup

  1. customAfter evaporation of the solvent the residue
  2. customwas purified with chromatographic methods

Sources & evidence

ORD record
ord-c915636d2c4540ab9a872fe9ffecfdec
Source dataset
uspto-grants-2012_10
Patent number
US08278345B2

Reaction notes

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