反应详情

7-Bromo-1-chloroisoquinoline 2-oxide (1.43 g, 5.56 mmol) and POCl3 (20 mL) were heated at reflux for 2 h. The reaction mixture was cooled and carefully poured onto a mixture of ice/water (500 g), stirred for 1 h and the pH adjusted to 10.0 with 10M NaOH. The mixture was extracted with chloroform (2×100 mL) and the chloroform extracts washed with brine, dried over MgSO4, filtered and concentrated to give the title compound (1.40 g). LRMS (M+H)+=276.0.

1. temperatureat reflux for 2 h
2. temperatureThe reaction mixture was cooled
3. extractionThe mixture was extracted with chloroform (2×100 mL)
4. washthe chloroform extracts washed with brine
5. dry with materialdried over MgSO4
6. filtrationfiltered
7. concentrationconcentrated