1H-Imidazole-1-propanamine → HCID 131729978, compound

HRID 2060653Notes

Reaction equation

HRID 2060653 reaction equation
CC(O[CH2:5][C:6]1[C:11]2=[CH:12][CH:13]=[C:14](C=O)[C:10]2=[CH:9]OC=1)=O.[NH2:17]CCC[N:21]1[CH:25]=[CH:24][N:23]=[CH:22]1>C(Cl)(Cl)Cl>[CH:9]1[NH:17][CH:5]=[CH:6][C:11]2[C:10]=1[CH:14]=[CH:13][CH:12]=2.[NH:21]1[CH:25]=[CH:24][N:23]=[CH:22]1

Participants

4

Reactant 2

HCID 787361H-Imidazole-1-propanamineHCID 159846Baldrinal2×

Product 1

HCID 131729978HCID 131729978, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Baldrinal (2) (2.7 g) was reacted with 1-(3-aminopropyl)-imidazole (2.94 g) in 2 ml of chloroform. After stirring for 10 min at room temperature, no baldrinal was detected in the reaction mixture. Compound (5) was separated on column with silica using 20:1 CHCl3:MeOH solvent system, and 26.7 mg of product was collected.

Workup

  1. customCompound (5) was separated on column with silica using 20:1 CHCl3
  2. customMeOH solvent system, and 26.7 mg of product was collected

Sources & evidence

ORD record
ord-31900e4fcf274aeba7797ec700652a70
Source dataset
uspto-grants-2012_10
Patent number
US08278451B2

Reaction notes

Loading…