反应详情

A solution of 4M hydrogen chloride in dioxane (834.8 μL; 3.3 mmol) is added to tert-butyl 7a-(5-(5-fluoropicolinamido)-2-fluorophenyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-ylcarbamate (91 mg; 167.0 μmol) and stirred at ambient temperature. After 2 days, the reaction mixture is concentrated in vacuo. The residue is dissolved in minimal dichloromethane and methanol. Ether and hexane are added. The product is precipitated as the salt which is separated from the mother liquor by centrifugation and placed under vacuum to remove any solvent present to give the title compound (58 mg; 125 mmol). LC-ES/MS m/e 391 (M+1); TR=1.675.

1. concentrationthe reaction mixture is concentrated in vacuo
2. dissolutionThe residue is dissolved in minimal dichloromethane
3. additionEther and hexane are added
4. customThe product is precipitated as the salt which
5. customis separated from the mother liquor by centrifugation
6. customto remove any solvent present