Hydrochloric Acid → HCID 57504940, compound

HRID 2060804Notes

Reaction equation

HRID 2060804 reaction equation
[N:1]1[CH:6]=[C:5]([C:7]2[CH:8]=[C:9]([C@:13]34[CH2:21][CH2:20][CH2:19][C@H:18]3[CH2:17][S:16][C:15]([NH2:22])=[N:14]4)[CH:10]=[CH:11][CH:12]=2)[CH:4]=[N:3][CH:2]=1.[ClH:23]>CO.O1CCOCC1>[ClH:23].[ClH:23].[N:1]1[CH:6]=[C:5]([C:7]2[CH:8]=[C:9]([C@:13]34[CH2:21][CH2:20][CH2:19][C@H:18]3[CH2:17][S:16][C:15]([NH2:22])=[N:14]4)[CH:10]=[CH:11][CH:12]=2)[CH:4]=[N:3][CH:2]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57504941HCID 57504941, compound

Product 1

HCID 57504940HCID 57504940, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To the solution of (4aR,7aS)-7a-(3-(pyrimidin-5-yl)phenyl)-4,4a,5,6,7,7a-hexahydrocyclopenta[d][1,3]thiazin-2-amine (0.482 g, 1.55 mmol) in methanol (2 mL) is added 4 N HCl in 1,4-dioxane (2 mL) at room temperature. The resulting mixture is stirred at room temperature for 1 hour and is concentrated under reduced pressure to give the title compound (0.595 g, 100%). ES/MS m/e: 311 (M+1).

Workup

  1. concentrationis concentrated under reduced pressure

Sources & evidence

ORD record
ord-d8051bef8ceb4912b9bcf02a96feaaaa
Source dataset
uspto-grants-2012_10
Patent number
US08278441B2

Reaction notes

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