HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 50903135, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 50903136 | HCID 50903136 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 50903135 | HCID 50903135 | 100% |
Reaction Steps
A solution of 1 M hydrogen chloride in diethyl ether is added in excess to (4aS,7aS)-7a-(4-fluoro-3-(pyrimidin-5-yl)phenyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-amine (22 mg, 66.59 mmol) in minimal dichloromethane. The solvent is removed under reduced pressure to give the title compound (27 mg, 100%). LC-ES/MS m/e: 331 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278441B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-b71630f60ad54913b951aa3801028648 |
| Source note | uspto-grants-2012_10 |