Hydrochloric Acid → HCID 50903135, compound

HRID 2060808Notes

Reaction equation

HRID 2060808 reaction equation
[ClH:1].[F:2][C:3]1[CH:8]=[CH:7][C:6]([C@:9]23[CH2:17][O:16][CH2:15][C@H:14]2[CH2:13][S:12][C:11]([NH2:18])=[N:10]3)=[CH:5][C:4]=1[C:19]1[CH:20]=[N:21][CH:22]=[N:23][CH:24]=1>C(OCC)C.ClCCl>[ClH:1].[ClH:1].[F:2][C:3]1[CH:8]=[CH:7][C:6]([C@:9]23[CH2:17][O:16][CH2:15][C@H:14]2[CH2:13][S:12][C:11]([NH2:18])=[N:10]3)=[CH:5][C:4]=1[C:19]1[CH:20]=[N:21][CH:22]=[N:23][CH:24]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 50903136HCID 50903136, compound

Product 1

HCID 50903135HCID 50903135, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

A solution of 1 M hydrogen chloride in diethyl ether is added in excess to (4aS,7aS)-7a-(4-fluoro-3-(pyrimidin-5-yl)phenyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-amine (22 mg, 66.59 mmol) in minimal dichloromethane. The solvent is removed under reduced pressure to give the title compound (27 mg, 100%). LC-ES/MS m/e: 331 (M+1).

Workup

  1. customThe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-b71630f60ad54913b951aa3801028648
Source dataset
uspto-grants-2012_10
Patent number
US08278441B2

Reaction notes

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