Trifluoroacetic acid → N-[2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl]methanesulfonamide

HRID 2060816Notes

Reaction equation

HRID 2060816 reaction equation
FC(F)(F)C(O)=O.C(OC(=O)[N:14]([S:32]([CH3:35])(=[O:34])=[O:33])[CH2:15][CH2:16][C:17]1[CH:22]=[CH:21][C:20]([B:23]2[O:27][C:26]([CH3:29])([CH3:28])[C:25]([CH3:31])([CH3:30])[O:24]2)=[CH:19][CH:18]=1)(C)(C)C.[OH-].[Na+]>ClCCl>[CH3:28][C:26]1([CH3:29])[C:25]([CH3:30])([CH3:31])[O:24][B:23]([C:20]2[CH:19]=[CH:18][C:17]([CH2:16][CH2:15][NH:14][S:32]([CH3:35])(=[O:34])=[O:33])=[CH:22][CH:21]=2)[O:27]1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 14798Sodium HydroxideHCID 22663801HCID 22663801, compound

Product 1

HCID 11472815N-[2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl]methanesulfonamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (10 mL) was added to a 0° C. solution of tert-butyl(methylsulfonyl){2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl}carbamate (from the previous step, assumed 19.7 mmol) in dichloromethane (100 mL). The reaction mixture was allowed to warm to room temperature and stir for 18 hours. It was then cooled to 0° C. and brought to pH 10.5 with a 4N aqueous sodium hydroxide solution. The organic layer was washed with saturated aqueous sodium chloride solution, dried over magnesium sulfate, filtered and concentrated in vacuo. The residue was purified via silica gel chromatography (Gradient: 0% to 5% methanol in dichloromethane) to provide the title compound as an off-white solid. Yield: 2.5 g, 7.7 mmol, 39% over two steps. LCMS m/z 326.1 (M+1). 1H NMR (400 MHz, CDCl3) δ 1.35 (s, 12H), 2.84 (s, 3H), 2.90 (t, J=6.8 Hz, 2H), 3.42 (dt, J=6.6, 6.6 Hz, 2H), 4.18 (br t, J=6 Hz, 1H), 7.23 (d, J=8.1 Hz, 2H), 7.78 (d, J=8.1 Hz, 2H).

Workup

  1. temperatureIt was then cooled to 0° C.
  2. washThe organic layer was washed with saturated aqueous sodium chloride solution
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo
  6. customThe residue was purified via silica gel chromatography (Gradient: 0% to 5% methanol in dichloromethane)

Sources & evidence

ORD record
ord-b938a0578f5f4ed788a8a441bddeb09a
Source dataset
uspto-grants-2012_10
Patent number
US08278457B2

Reaction notes

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