反应详情

温度

80 °C

To 6-(1-methylisoquinolin-4-yloxy)nicotinamide (Preparation 19) (135 mg, 0.48 mmol) in dioxane (6 mL) under argon was added selenium dioxide (54 mg, 0.48 mmol). The mixture was heated to 80° C. for 3 h after which time selenium dioxide (54 mg, 0.48 mmol) was added. After a further 0.5 h at 80° C. the mixture was cooled, filtered through Celite and washed with EtOAc (50 mL). The organic phase was washed with NaHCO3 (30 mL), water (30 mL), brine (30 mL) and dried (MgSO4). Solvent was removed in vacuo to give the title compound: RT=2.93 min; m/z (ES+)=294.1 [M+H]+.

1. additionwas added
2. filtrationfiltered through Celite
3. washwashed with EtOAc (50 mL)
4. washThe organic phase was washed with NaHCO3 (30 mL), water (30 mL), brine (30 mL)
5. dry with materialdried (MgSO4)
6. customSolvent was removed in vacuo