反应详情

4-Oxo-1,4-dihydroquinoline-8-carbonitrile (0.40 g, 0.24 mmol, WO2004/113303) and phosphorous oxychloride (10 mL) were heated to 100° C. for 1.5 h. Solvent removed in vacuo. EtOAc (50 mL) was added and organic phase washed with sat. aqueous Na2CO3 solution, brine (20 mL) and dried (MgSO4). Solvent removed in vacuo to give the title compound: RT=3.09 min; m/z (ES+)=189.0 [M+H]+.

1. customSolvent removed in vacuo
2. additionEtOAc (50 mL) was added
3. washorganic phase washed with sat. aqueous Na2CO3 solution, brine (20 mL)
4. dry with materialdried (MgSO4)
5. customSolvent removed in vacuo