2-Cyclohexylethanamine hydrochloride → 4-{4-[(2-Cyclohexylethylamino)methyl]isoquinolin-1-yloxy}benzamide

HRID 2060898Notes

Reaction equation

HRID 2060898 reaction equation
[CH:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([O:13][C:14]2[CH:22]=[CH:21][C:17]([C:18]([NH2:20])=[O:19])=[CH:16][CH:15]=2)=[N:5][CH:4]=1)=O.Cl.[CH:24]1([CH2:30][CH2:31][NH2:32])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1>>[CH:24]1([CH2:30][CH2:31][NH:32][CH2:1][C:3]2[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6]([O:13][C:14]3[CH:22]=[CH:21][C:17]([C:18]([NH2:20])=[O:19])=[CH:16][CH:15]=3)=[N:5][CH:4]=2)[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 2000082-Cyclohexylethanamine hydrochlorideHCID 594012974-(4-Formylisoquinolin-1-yloxy)benzamide

Product 1

HCID 251214784-{4-[(2-Cyclohexylethylamino)methyl]isoquinolin-1-yloxy}benzamide

Procedure

Using the procedure outlined in Example 96, 4-(4-formylisoquinolin-1-yloxy)-benzamide (Preparation 16) and 2-cyclohexylethylamine hydrochloride were converted to the title compound: RT=2.70 min; m/z (ES+)=404.0 [M+H]+.

Sources & evidence

ORD record
ord-0b9c711dc98a462f8d01a4c3c8288606
Source dataset
uspto-grants-2012_10
Patent number
US08278442B2

Reaction notes

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