Hydrochloric Acid → HCID 67309791, compound

4-(2-(tert-Butoxycarbonylamino)-2-methylpropyl)-4-methylmorpholin-4-ium iodide (840 mg, 2.1 mmol) was dissolved in methanol (5 ml). To the solution was added 4M hydrogen chloride in dioxane (25 ml), and stirred for 4 hours at room temperature. The reaction mixture was concentrated and dissolved in water. Silver oxide (1.0 g) was added to the aqueous solution and the mixture was stirred at room temperature for 30 minutes. The solution was filtered through Celite®, and concentrated hydrochloric acid (0.5 ml) was added to the solution. The solution was filtered through Celite® a second time, and the aqueous solution was concentrated in vacuo to give 380 mg (87%) of 4-(2-amino-2-methylpropyl)-4-methylmorpholin-4-ium chloride. MS (ESI+) calculated for C9H21N2O+: 173.16, Found: 173 (M+).

1. concentrationThe reaction mixture was concentrated
2. dissolutiondissolved in water
3. additionSilver oxide (1.0 g) was added to the aqueous solution
4. stirringthe mixture was stirred at room temperature for 30 minutes
5. filtrationThe solution was filtered through Celite®, and concentrated hydrochloric acid (0.5 ml)
6. additionwas added to the solution
7. filtrationThe solution was filtered through Celite® a second time
8. concentrationthe aqueous solution was concentrated in vacuo

ORD record

ord-bc0352f422f54b82803dc8787acf2361

Source dataset

uspto-grants-2012_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08278482B2