HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoylhydrazine → 2-benzoyl-N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)hydrazinecarbothioamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoylhydrazine | HCID 11955 | — |
| Reactant | 3-(5-isothiocyanato-2-methylphenyl)-1,7-dimethyl-1,6-naphthyridin-2(1H)-one | HCID 58369004 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-benzoyl-N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)hydrazinecarbothioamide | HCID 86656155 | — |
Reaction Steps
To a solution of 19 (50 mg, 0.16 mmol) in EtOH (1.0 mL), benzohydrazide (26 mg, 0.19 mmol) was added and stirred at rt for 2 h. The solvent was removed under vacuum to yield crude 2-benzoyl-N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)hydrazinecarbothioamide, which was used without purification. MS m/z 458.2 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278452B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-af5156f3b09e4fb7bf1cd9ffd509dd24 |
| Source note | uspto-grants-2012_10 |