Lithium Hydroxide → 3-Hydroxy-2-[(1-piperidinylcarbonyl)amino]propionic acid

200 mg (0.869 mmol) of methyl 3-hydroxy-2-[(1-piperidinylcarbonyl)-amino]propionate was dissolved in 6 ml of a solvent mixture of methanol:tetrahydrofuran (1:1). 1.04 ml (1.04 mmol) of 1 N aqueous lithium hydroxide solution was added to the obtained solution, and they were stirred at room temperature for 30 minutes. The reaction mixture was concentrated under reduced pressure, and the concentrate was acidified with 1 N aqueous hydrochloric acid solution. After extracting with ethyl acetate, the organic layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure to obtain the title compound.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. extractionAfter extracting with ethyl acetate
3. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
4. concentrationconcentrated under reduced pressure

ORD record

ord-fdba24fae8754b469cf272c50cff71e6

Source dataset

uspto-grants-2012_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08278329B2