HCID 66916056, compound → HCID 66915943, compound

HRID 2061429Notes

Reaction equation

HRID 2061429 reaction equation
[CH3:1][N:2]([CH3:16])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([N+:9]([O-])=O)[C:4]=1[S:12]([NH2:15])(=[O:14])=[O:13]>[Pd].CO>[NH2:9][C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([N:2]([CH3:16])[CH3:1])[C:4]=1[S:12]([NH2:15])(=[O:13])=[O:14]

Participants

4

Reactant 1

HCID 66916056HCID 66916056, compound

Product 1

HCID 66915943HCID 66915943, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 2-dimethylamino-6-nitro-benzenesulfonamide (753 mg, 3.07 mmol), Pd (10%) on charcoal (100 mg) and methanol (25 ml) is hydrogenated at 25° C. for 2 h. Pd is removed by filtration, the solvent evaporated and the residue crystallized from TBME/cyclohexane to give 2-amino-6-dimethylamino-benzenesulfonamide as a colorless solid.

Workup

  1. customPd is removed by filtration
  2. customthe solvent evaporated
  3. customthe residue crystallized from TBME/cyclohexane

Sources & evidence

ORD record
ord-be48c7d276344fcd8455744c0735d547
Source dataset
uspto-grants-2012_10
Patent number
US08283356B2

Reaction notes

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