Ammonium Hydroxide → Benzenesulfonamide, 2-methoxy-6-nitro-

HRID 2061442Notes

Reaction equation

HRID 2061442 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([N+:9]([O-:11])=[O:10])[C:4]=1[S:12](Cl)(=[O:14])=[O:13].[OH-].[NH4+:17]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([N+:9]([O-:11])=[O:10])[C:4]=1[S:12]([NH2:17])(=[O:14])=[O:13]

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 866088532-Methoxy-6-nitrobenzenesulfonyl chloride

Product 1

HCID 66915997Benzenesulfonamide, 2-methoxy-6-nitro-

Procedure

A mixture of 2-methoxy-6-nitro-benzenesulfonyl chloride (12.8 g, 50.87 mmol) and 25% ammonium hydroxide is swirled at 65° C. on a rotavap. After 15 min the volume of the resulting solution is reduced to half by evaporation of volatiles at reduced pressure. Collecting the precipitate by filtration after cooling gives 2-methoxy-6-nitro-benzenesulfonamide.

Workup

  1. customis swirled at 65° C. on a rotavap
  2. customAfter 15 min the volume of the resulting solution is reduced to half by evaporation of volatiles at reduced pressure
  3. customCollecting the precipitate
  4. filtrationby filtration
  5. temperatureafter cooling

Sources & evidence

ORD record
ord-dcf60a53b1784762a245b70f2b3861bb
Source dataset
uspto-grants-2012_10
Patent number
US08283356B2

Reaction notes

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