反应详情

温度

30 °C

A mixture of N-(3-fluoro-5-methyl-2-nitrophenyl)-1-(tetrahydro-2H-pyran-4-yl)-4-piperidinamine (10 g), ethyl acetate (200 ml) and 10% Pd/C (1 g), was stirred at about 30° C. under hydrogen pressure for 9 hours. The catalyst was filtered and the filtrate concentrated. The residue was stirred with ethyl acetate (20 ml) and hexane (40 ml) for 1 hour at room temperature then filtered and the solid dried at 50° C. to give the title compound as a solid (6.3 g).

1. filtrationThe catalyst was filtered
2. concentrationthe filtrate concentrated
3. stirringThe residue was stirred with ethyl acetate (20 ml) and hexane (40 ml) for 1 hour at room temperature
4. filtrationthen filtered
5. customthe solid dried at 50° C.