反应详情

[(2-Trifluoromethyl-7-bromo-1H-indol-5-yl)methyl]amine (Intermediate 9, 230 mg, 0.785 mmol) was dissolved in DCM (10 mL) and 6-(trifluoromethyl)nicotinoyl chloride (ABCR; 181 mg, 0.863 mmol) was added. Et3N (0.219 mL, 1.570 mmol) was added and the reaction mixture was then left to stir at room temperature for 30 min. The reaction mixture was quenched with water then the organic layer was collected, dried (MgSO4), filtered and evaporated to dryness. The resulting residues were purified by MDAP to give the title compound, (200 mg);

1. waitthe reaction mixture was then left
2. customThe reaction mixture was quenched with water
3. customthe organic layer was collected
4. dry with materialdried (MgSO4)
5. filtrationfiltered
6. customevaporated to dryness
7. customThe resulting residues were purified by MDAP