HCID 59268910, compound → HCID 59268895, compound

HRID 2061616Notes

Reaction equation

HRID 2061616 reaction equation
C=C[CH2:3][CH:4]([C:8]1[CH:16]=[CH:15][C:11]2[O:12][CH2:13][O:14][C:10]=2[CH:9]=1)[CH2:5][CH:6]=[CH2:7]>C(Cl)Cl.Cl[Ru](=CC1C=CC=CC=1)([P](C1CCCCC1)(C1CCCCC1)C1CCCCC1)([P](C1CCCCC1)(C1CCCCC1)C1CCCCC1)Cl>[CH:4]1([C:8]2[CH:16]=[CH:15][C:11]3[O:12][CH2:13][O:14][C:10]=3[CH:9]=2)[CH2:3][CH:7]=[CH:6][CH2:5]1

Participants

4

Reactant 1

HCID 59268910HCID 59268910, compound

Product 1

HCID 59268895HCID 59268895, compoundYield 32.3%

Reagents, catalysts & solvents 2

HCID 178479819HCID 178479819, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

To a solution of Grubbs I (0.345 mmol, 0.284 g) in CH2Cl2 was added diene 97 (6.91 mmol, 1.49 g). The reaction mixture was stirred at room temperature for 48 h. The reaction mixture was purified by flash chromatography (hexanes) to afford compound 98 (0.42 g, 32%).

Workup

  1. customThe reaction mixture was purified by flash chromatography (hexanes)

Sources & evidence

ORD record
ord-ec35891ef7e6461da92483061160a1c5
Source dataset
uspto-grants-2012_10
Patent number
US08283358B2

Reaction notes

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