Trifluoroacetic acid → HCID 67095119, compound

HRID 2061688Notes

Reaction equation

HRID 2061688 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH2:8]([N:15](C(OC(C)(C)C)=O)[NH:16][C:17](=[O:44])[C:18](=[O:43])[CH:19]([NH:27][C:28]([C@H:30]1[CH2:34][CH2:33][C:32](=[O:35])[N:31]1[CH2:36][C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)=[O:29])[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>C(Cl)Cl>[CH2:36]([N:31]1[C:32](=[O:35])[CH2:33][CH2:34][C@@H:30]1[C:28]([NH:27][CH:19]([C:18](=[O:43])[C:17]([NH:16][NH:15][CH2:8][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)=[O:44])[CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)=[O:29])[C:37]1[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=1.[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66645054HCID 66645054, compound

Product 1

HCID 67095119HCID 67095119, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (TFA) (0.2 mL, 2.60 mmol) was added to a solution of tert-butyl 1-benzyl-2-(3-((R)-1-benzyl-5-oxopyrrolidine-2-carboxamido)-2-oxo-4-phenylbutanoyl)hydrazinecarboxylate (110 mg, 0.184 mmol) in DCM (2 mL). After stirring for 4 h the solvent was removed in vacuo and the residue obtained was triturated with diethyl ether providing the title compound (48 mg, 43%).

Workup

  1. customwas removed in vacuo
  2. customthe residue obtained
  3. customwas triturated with diethyl ether providing the title compound (48 mg, 43%)

Sources & evidence

ORD record
ord-318668f2dc414132a0203cb98e98b3b8
Source dataset
uspto-grants-2012_10
Patent number
US08283363B2

Reaction notes

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