Sodium Bicarbonate → HCID 86632372, compound

HRID 2061785Notes

Reaction equation

HRID 2061785 reaction equation
[C:1]([OH:9])(=[S:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:10]([N:13]1[C:25]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[C:19]2[C:14]1=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:11]=[CH2:12].C(=O)(O)[O-].[Na+]>C1(C)C=CC=CC=1.O>[CH:15]1[C:14]2[N:13]([CH2:10][CH2:11][CH2:12][S:8][C:1](=[O:9])[C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[C:19]=2[CH:18]=[CH:17][CH:16]=1

Participants

6

Reactant 3

HCID 516892Sodium BicarbonateHCID 30903939-AllylcarbazoleHCID 178526132HCID 178526132, compound

Product 1

HCID 86632372HCID 86632372, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 1140TolueneSolvent

Procedure

Thiobenzoic acid (30 g, 0.20 mol) was added to 9-allylcarbazole (11.9 g, 0.057 mol) in 100 mL toluene, and the reaction was carried out at 90° C. with argon purge via radical mechanism using AIBN as the initiator (1.8 g, 11 mmol, in 300 mg increments at 1 hr intervals). After 6 hrs the reaction mixture was poured into a 1 L separatory funnel containing 20 g sodium bicarbonate (NaHCO3, 0.24 mol) in 250 mL water, extracted with 100 mL chloroform, and the organic phase was washed twice with 200 mL water before solvent removal under reduced pressure. The crude product was subsequently washed in 100 mL hot hexane, 150 mL ethanol, and finally 150 mL of 15:1 ethanol:chloroform. Evaporation of leftover solvent at 80° C. under reduced pressure yielded compound 16 in ca. 90% purity as a dark brown, viscous syrup which solidified upon cooling (9.35 g, 0.024 mol, 42% yield, ˜10% wt dibenzoyl disulfide). 1H NMR (300 MHz, CDCl3): δ=8.10 (d, 2 carbazole H, J=8.1 Hz), 8.00-7.95 (m, 2 aromatic H ortho to COS), 7.62-7.41 (m, 3 aromatic H meta and para to COS plus 4 carbazole H), 7.27-7.19 (m, 2 carbazole H), 4.43 (t, NCH2, J=6.9 Hz), 3.06 (t, SCH2, J=6.9 Hz), 2.26 (tt, NCH2CH2CH2S, J=6.9, 6.9 Hz). 13C NMR (300 MHz, CDCl3): δ=191.56, 140.25, 136.88, 133.50, 128.65, 127.23, 125.75, 122.91, 120.41, 119.00, 108.55, 41.65, 28.95, 26.41.

Workup

  1. customwas carried out at 90° C. with argon
  2. custompurge via radical mechanism
  3. customas the initiator (1.8 g, 11 mmol, in 300 mg increments at 1 hr intervals)
  4. additionAfter 6 hrs the reaction mixture was poured into a 1 L separatory funnel
  5. extractionextracted with 100 mL chloroform
  6. washthe organic phase was washed twice with 200 mL water before solvent removal under reduced pressure
  7. washThe crude product was subsequently washed in 100 mL hot hexane
  8. customEvaporation of leftover solvent at 80° C. under reduced pressure

Sources & evidence

ORD record
ord-aef447f998ed4b848b5777c4a394eb90
Source dataset
uspto-grants-2012_10
Patent number
US08283438B2

Reaction notes

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