反应详情

温度

0 °C

5-Bromo-2-(3-ethylureido)pyridine-4-carbothioamide (Intermediate 3, 6.06 g, 20 mmol) was suspended in acetonitrile (150 ml). 1-Bromobutan-2-one (30 mmol) was added and the reaction mixture was heated at reflux for 16 h. The reaction was cooled to 0° C. and the suspension was filtered. The solid was washed with acetonitrile (50 ml), collected, and dried in a vacuum oven at 50° C. for 4 hours to give an off white solid.

1. temperaturethe reaction mixture was heated
2. temperatureat reflux for 16 h
3. filtrationthe suspension was filtered
4. washThe solid was washed with acetonitrile (50 ml)
5. customcollected
6. customdried in a vacuum oven at 50° C. for 4 hours
7. customto give an off white solid