反应详情

温度

23 °C

Ethyl 1-((1-(tert-butoxycarbonyl)pyrrolidin-3-yl)methyl)-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylate (Intermediate 131, 3.0 g, 5.7 mmol) was dissolved in 1,4-dioxane (15 mL) and 4.0M hydrogen chloride in 1,4-dioxane (10 mL) was added. The reaction was stirred at 23° C. for 3 h, and the solvent was removed in vacuo. The solid was then dried in a vacuum oven at 50° C. for 18 h to give 2.64 g (quant. yield) of ethyl 6-iodo-4-oxo-1-(piperidin-3-yl)-1,4-dihydroquinoline-3-carboxylate hydrochloride as a yellow solid.

1. customthe solvent was removed in vacuo
2. customThe solid was then dried in a vacuum oven at 50° C. for 18 h