反应详情

To a suspension of 30.0 g 1-Hydroxy-naphthalene-2-carboxylic acid in 600 ml chloroform a mixture of 14.9 ml sulfuryl chloride and 20 ml chloroform was added dropwise. After stirring the reaction for 8 h at room temperature the precipitated product was isolated by filtration, washed with dichloromethane and recrystallized from isopropanol/water to yield 25.1 g of 4-chloro-1-hydroxy-naphthalene-2-carboxylic acid as off-white solid.

1. additionwas added dropwise
2. customthe reaction for 8 h at room temperature the precipitated product
3. customwas isolated by filtration
4. washwashed with dichloromethane
5. customrecrystallized from isopropanol/water