Hydrochloric Acid → HCID 44828665, compound

HRID 2062267Notes

Reaction equation

HRID 2062267 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][C@@H:10]([CH2:14][NH:15][C:16](=[O:25])[O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:9]1)=O)(C)(C)C.[ClH:26].O1CCOCC1>>[ClH:26].[NH:8]1[CH2:13][CH2:12][CH2:11][C@@H:10]([CH2:14][NH:15][C:16](=[O:25])[O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:9]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 45158795(S)-1-Boc-3-(Cbz-amino-methyl)-piperidine

Product 1

HCID 44828665HCID 44828665, compound

Procedure

Benzyl ((S)-1-(tert-butoxycarbonyl)piperidin-3-yl)methylcarbamate (895 mg, 2.57 mmol) was treated with a 4.0 M HCl solution in dioxane (3.2 mL, 12.85 mmol). Formation of a white precipitate was observed. After 3 h, complete conversion of starting material was seen by TLC. The solvent and excess HCl were removed under reduced pressure to obtain benzyl ((R)-piperidin-3-yl)methylcarbamate hydrochloride as a white solid.

Workup

  1. customThe solvent and excess HCl were removed under reduced pressure

Sources & evidence

ORD record
ord-b7956c141a96463b8fc68e37cfd20636
Source dataset
uspto-grants-2012_10
Patent number
US08283354B2

Reaction notes

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