HCID 12571053, compound → HCID 178513806, compound

HRID 2063156Notes

Reaction equation

HRID 2063156 reaction equation
C[O:2][C:3]1[C:4]([C:10]([NH2:12])=[O:11])=[N:5][CH:6]=[CH:7][N+:8]=1[O-:9]>Br>[OH:2][C:3]1[C:4]([C:10]([NH2:12])=[O:11])=[N:5][CH:6]=[CH:7][N+:8]=1[O-:9]

Participants

3

Reactant 1

HCID 12571053HCID 12571053, compound

Product 1

HCID 178513806HCID 178513806, compoundYield 65.4%

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Conditions

Temperature
45 °C

Procedure

In 0.5 mL of 47% aqueous solution of hydrogen bromide is dissolved 0.05 g of 3-methoxy-2-pyrazinecarboxamide-4-oxide obtained according to the method described in literature [Eur. J. Med. Chem., 15(2), 157-163 (1980)]. The solution is stirred at 45° C. for 2 hours. The deposited crystals are collected by filtration and washed successively with ethanol and diethyl ether to obtain 0.03 g of 3-hydroxy-2-pyrazinecarboxamide-4-oxide.

Workup

  1. customobtained
  2. filtrationThe deposited crystals are collected by filtration
  3. washwashed successively with ethanol and diethyl ether

Sources & evidence

ORD record
ord-2a6eb1a8897a462bab190240b0ee3dba
Source dataset
uspto-grants-2012_10
Patent number
USRE043748E1

Reaction notes

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