2-Methylthio-2-imidazoline hydroiodide → HCID 69234672, compound

HRID 2063241Notes

Reaction equation

HRID 2063241 reaction equation
Cl.[CH2:2]([C:6]1[CH:11]=[CH:10][C:9]([C@@H:12]([CH3:20])[C:13]([NH:15][CH2:16][CH2:17][CH2:18][NH2:19])=[O:14])=[CH:8][CH:7]=1)[CH:3]([CH3:5])[CH3:4].CS[C:23]1[NH:24][CH2:25][CH2:26][N:27]=1>>[CH2:2]([C:6]1[CH:11]=[CH:10][C:9]([C@@H:12]([CH3:20])[C:13]([NH:15][CH2:16][CH2:17][CH2:18][NH:19][C:23]2[NH:27][CH2:26][CH2:25][N:24]=2)=[O:14])=[CH:8][CH:7]=1)[CH:3]([CH3:5])[CH3:4]

Participants

3

Reactant 2

HCID 883692-Methylthio-2-imidazoline hydroiodideHCID 69235497HCID 69235497, compound

Product 1

HCID 69234672HCID 69234672, compound

Procedure

The (R)2-[(4-isobutylphenyl)-N-3-(aminopropyl)propionamide hydrochloride (see example 5) is converted in the free amine and treated with 2-methylthio-2-imidazoline iodohydrate (commercial reactant) according to the above cited Bodanszky procedure (J. Am. Chem. Soc., 86, 4452, 1964) to give (R)2-(4′-isobutylphenyl)-N-[3-(imidazolin-2-yl)aminopropyl]propionamide

Sources & evidence

ORD record
ord-d9d9db9e6f4348e8889b2120646b0243
Source dataset
uspto-grants-2012_10
Patent number
US08288368B2

Reaction notes

Loading…