Hydrochloric Acid → HCID 68512581, compound

HRID 2063257Notes

Reaction equation

HRID 2063257 reaction equation
Cl.[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:27]([C:28]3[CH:33]=[CH:32][N:31]=[C:30]([NH:34][CH:35]([CH3:37])[CH3:36])[N:29]=3)=[C:12]3[CH2:13][N:14](C(OCC4C=CC=CC=4)=O)[CH2:15][CH2:16][N:11]3[N:10]=2)=[CH:5][CH:4]=1>CO.[Pd]>[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:27]([C:28]3[CH:33]=[CH:32][N:31]=[C:30]([NH:34][CH:35]([CH3:37])[CH3:36])[N:29]=3)=[C:12]3[CH2:13][NH:14][CH2:15][CH2:16][N:11]3[N:10]=2)=[CH:5][CH:4]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 70864655HCID 70864655, compound2×

Product 1

HCID 68512581HCID 68512581, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent2×

Procedure

Palladium (10% on activated carbon, 25 mg) and 2 M hydrogen chloride in methanol (20 mL) were added to a solution of phenylmethyl 2-(4-fluorophenyl)-6,7-dihydro-3-[2-[(1-methylethyl)amino]-4-pyrimidinyl]pyrazolo[1,5-a]pyrazine-5(4H)-carboxylate (i.e. the product of Step D) (0.50 g, 0.14 mmol) in methanol (30 mL). The resulting suspension was shaken on a Parr apparatus under hydrogen gas (68.9 kPa) for 18 h. The resulting suspension was filtered and concentrated to dryness to give 0.42 g of the title product, a compound of the present invention, as a white solid.

Workup

  1. filtrationThe resulting suspension was filtered
  2. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-ad71dc1ee5f447789677de811f0838ed
Source dataset
uspto-grants-2012_10
Patent number
US08288375B2

Reaction notes

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