Isopropylamine → HCID 68512534, compound

HRID 2063266Notes

Reaction equation

HRID 2063266 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]([C:17]3[CH:22]=[CH:21][N:20]=[C:19](S(C)(=O)=O)[N:18]=3)=[C:15]3[N:10]([CH2:11][O:12][CH2:13][CH2:14]3)[N:9]=2)=[CH:4][CH:3]=1.[CH:27]([NH2:30])([CH3:29])[CH3:28]>C(Cl)(Cl)Cl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]([C:17]3[CH:22]=[CH:21][N:20]=[C:19]([NH:30][CH:27]([CH3:29])[CH3:28])[N:18]=3)=[C:15]3[N:10]([CH2:11][O:12][CH2:13][CH2:14]3)[N:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 68511827HCID 68511827, compound2×

Product 1

HCID 68512534HCID 68512534, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A solution of 2-(4-fluorophenyl)-4,5-dihydro-3-[2-(methylsulfonyl)-4-pyrimidinyl]-7H-pyrazolo[1,5-c][1,3]oxazine (i.e. the product of Step E) (0.15 g, 0.4 mmol) and isopropylamine (0.95 g, 16 mmol) in 2.5 mL of chloroform in a sealed tube was heated in a microwave reactor for 1 h at 120° C. The reaction mixture was then concentrated under reduced pressure and purified by medium pressure liquid chromatography using 0-100% ethyl acetate in hexanes as eluant to give 100 mg of the title product, a compound of the present invention, as a white solid.

Workup

  1. concentrationThe reaction mixture was then concentrated under reduced pressure
  2. custompurified by medium pressure liquid chromatography

Sources & evidence

ORD record
ord-81db4031564e4a36a21762b1ff0fae12
Source dataset
uspto-grants-2012_10
Patent number
US08288375B2

Reaction notes

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