Isopropylamine → HCID 68512534, compound

Participants

Reaction Steps

A solution of 2-(4-fluorophenyl)-4,5-dihydro-3-[2-(methylsulfonyl)-4-pyrimidinyl]-7H-pyrazolo[1,5-c][1,3]oxazine (i.e. the product of Step E) (0.15 g, 0.4 mmol) and isopropylamine (0.95 g, 16 mmol) in 2.5 mL of chloroform in a sealed tube was heated in a microwave reactor for 1 h at 120° C. The reaction mixture was then concentrated under reduced pressure and purified by medium pressure liquid chromatography using 0-100% ethyl acetate in hexanes as eluant to give 100 mg of the title product, a compound of the present invention, as a white solid.

Provenance & Evidence