Hydrochloric Acid → HCID 66811319, compound

HRID 2063277Notes

Reaction equation

HRID 2063277 reaction equation
[OH:1][CH:2]1[CH2:9][N:8]2[C:4](=[N:5][C:6]3[CH:13]=[C:12]([N+:14]([O-])=O)[CH:11]=[CH:10][C:7]=32)[CH2:3]1.[ClH:17].[H][H]>C(O)C.[Pd]>[ClH:17].[NH2:14][C:12]1[CH:11]=[CH:10][C:7]2[N:8]3[CH2:9][CH:2]([OH:1])[CH2:3][C:4]3=[N:5][C:6]=2[CH:13]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 66811769HCID 66811769, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 66811319HCID 66811319, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 0.3 g (1.36 mmol) of the 2,3-dihydro-2-hydroxy-6-nitro-1H-pyrrolo[1,2-a]benzimidazole obtained in step IX-2 and of 100 mg of palladium-on-charcoal at 10% in 15 ml of ethanol and 2 ml of 1N hydrochloric acid is stirred for 5 hours at 20° C. under 4 bar of hydrogen. After this period of time, the reaction mixture is filtered over a celite buffer, the filtrate is concentrated under reduced pressure, and 0.35 g of the expected product is obtained in the form of a solid.

Workup

  1. waitAfter this period of time
  2. filtrationthe reaction mixture is filtered over a celite buffer, the filtrate
  3. concentrationis concentrated under reduced pressure

Sources & evidence

ORD record
ord-3f6edb8409224b3a8c3cccaa96e9502b
Source dataset
uspto-grants-2012_10
Patent number
US08288376B2

Reaction notes

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